19 research outputs found
The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases
This article analyzes the "Global Burden of Disease Study 2010" and examines the study's implications for neglected tropical diseases
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A Comparative Risk Assessment Of Burden Of Disease And Injury Attributable To 67 Risk Factors And Risk Factor Clusters In 21 Regions, 1990–2010: A Systematic Analysis For The Global Burden Of Disease Study 2010
Background Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time
Global numbers of infection and disease burden of soil transmitted helminth infections in 2010
BACKGROUND: Quantifying the burden of parasitic diseases in relation to other diseases and injuries requires reliable estimates of prevalence for each disease and an analytic framework within which to estimate attributable morbidity and mortality. Here we use data included in the Global Atlas of Helminth Infection to derive new global estimates of numbers infected with intestinal nematodes (soil-transmitted helminths, STH: Ascaris lumbricoides, Trichuris trichiura and the hookworms) and use disability-adjusted life years (DALYs) to estimate disease burden. METHODS: Prevalence data for 6,091 locations in 118 countries were sourced and used to estimate age-stratified mean prevalence for sub-national administrative units via a combination of model-based geostatistics (for sub-Saharan Africa) and empirical approaches (for all other regions). Geographical variation in infection prevalence within these units was approximated using modelled logit-normal distributions, and numbers of individuals with infection intensities above given thresholds estimated for each species using negative binomial distributions and age-specific worm/egg burden thresholds. Finally, age-stratified prevalence estimates for each level of infection intensity were incorporated into the Global Burden of Disease Study 2010 analytic framework to estimate the global burden of morbidity and mortality associated with each STH infection. RESULTS: Globally, an estimated 438.9 million people (95% Credible Interval (CI), 406.3 - 480.2 million) were infected with hookworm in 2010, 819.0 million (95% CI, 771.7 - 891.6 million) with A. lumbricoides and 464.6 million (95% CI, 429.6 - 508.0 million) with T. trichiura. Of the 4.98 million years lived with disability (YLDs) attributable to STH, 65% were attributable to hookworm, 22% to A. lumbricoides and the remaining 13% to T. trichiura. The vast majority of STH infections (67%) and YLDs (68%) occurred in Asia. When considering YLDs relative to total populations at risk however, the burden distribution varied more considerably within major global regions than between them. CONCLUSION: Improvements in the cartography of helminth infection, combined with mathematical modelling approaches, have resulted in the most comprehensive contemporary estimates for the public health burden of STH. These numbers form an important benchmark upon which to evaluate future scale-up of major control efforts
Other NTDs in the Global Burden of Disease Study 2010 not listed in the “NTD and malaria” category.<sup>1</sup>
1<p>The table provides numbers of DALYs in millions as calculated in GBD 2010 <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002865#pntd.0002865-Murray1" target="_blank">[1]</a>. The diseases are not listed as NTDs in GBD 2010 and, with the exception of leprosy, these diseases are also not on the WHO list of 17 NTDs <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002865#pntd.0002865-Mathers1" target="_blank">[5]</a>. However, these conditions (as well as some other diarrheal diseases) are considered by <i>PLOS Neglected Tropical Diseases</i><a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002865#pntd.0002865-King1" target="_blank">[6]</a>.</p
Global trends in DALYs from NTDs, 1990 to 2010.
<p>*Estimation of percent (%) change is not from the means. Each metric in this figure is estimated on 1000 times in the modeling process, and then causes that have a high degree of uncertainty in their draw estimates can have skewed % change results. Abbreviations: UI, unit interval.</p
DALYs, YLDs, YLLs, and deaths from NTDs from the Global Burden of Disease Study.
<p>DALYs, YLDs, YLLs, and deaths from NTDs from the Global Burden of Disease Study.</p
Estimated DALYs (in millions) of the NTDs from the Global Burden of Disease Study 2010.
<p>* Relapsing fevers, typhus fever, spotted fever, Q fever, other rickettsioses, other mosquito-borne viral fevers, unspecified arthropod-borne viral fever, arenaviral haemorrhagic fever, toxoplasmosis, unspecified protozoal disease, taeniasis, diphyllobothriasis and sparganosis, other cestode infections, dracunculiasis, trichinellosis, strongyloidiasis, enterobiasis, and other helminthiases.</p
Expected number of cases in 2010 and 95% confidence intervals of the neglected tropical diseases (mean and uncertainty) as extrapolated from the Global Burden of Disease Study 2010.
<p>* This number includes 14.6 million people (13.2–16.1 million) with detectable skin microfilariae.</p>1<p>These are updated estimates recently published in Pullan et al. <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002865#pntd.0002865-Pullan2" target="_blank">[27]</a>.</p